HCG is a hormone that is naturally produced by the female placenta during a normal pregnancy. This medicine’s action is highly similar to luteinizing hormone (LH), because this hormone is known to be able to cause ovulation. If it is combined with other medicines and drugs, HCG Pregnyl is highly effective in helping female patients become pregnant. This drug can also help males patients that are suffering from fertility issues (a treatment with this medicine usually enables such cases to produce a higher amount of testosterone).

HCG Pregnyl is a popular medicine that is regularly prescribed to female patients as part of a regimen that is supposed to induce:

Ovulation induction in subfertility that is usually triggered by impaired follicle-ripening or by anovulation. - Luteal phase support.

HCG Pregnyl is a medicine that is regularly prescribed to male patients because of its ability to induce

Hypogonadotrophic hypogonadism. - Some patients who were suffering from idiopathic dysspermias have positively responded to a treatment with this medicine. - Delayed puberty which is regularly associated with an insufficient function of the gonadotrophic pituitary glands. - Cryptorchidism, (not the one that is triggered by an abnormal anatomical obstruction).

HCG Pregnyl is a popular medicine that helps both male and female patients deal with infertility. However, this medicine can also be used for some other purposes (to treat or to prevent some other medical conditions) that have not been listed here.

In the case of female patients who want to be treated with HCG Pregnyl:

- Since infertile female patients who undergo medically assisted reproduction (especially those who need in vitro fertilization), are known to often be suffering from tubal abnormalities, after a treatment with this drug they might experience much more ectopic pregnancies. This is why early ultrasound confirmation at the beginning of a pregnancy (to see whether the pregnancy is intrauterine or not) is crucial. - Pregnancies who have occurred after a treatment with this medicine are submitted to a higher risk of multiplets. - Female patients who have thrombosis, severe obesity or thrombophilia should not be prescribed this medicine as they have a higher risk of arterial or venous thromboembolic events after or during a treatment with HCG Pregnyl.

In the case of male patients: A prolonged treatment with HCG Pregnyl is known to regularly lead to increased production of androgen. Therefore:

Both male and female patients who have the following medical conditions must not start a treatment with HCG Pregnyl: - Hypersensitivity to this medicine or to any of its main ingredients. - Known or possible androgen-dependent tumors for example male breast carcinoma or prostatic carcinoma.

Dosage in the case of female patients: They should be administered one injection of 5 000-10 000 I.U. of this medicine. Dosage in the case of male patients: They should be administered an injection of 1000-2000 I.U. of medicine, from 2 to 3 times each week. It is best that each dose of HCG Pregnyl should be administered by an authorized medical healthcare provider.

This medicine’s acute toxicity is very low. The average symptoms of an overdose with HCG Pregnyl are not known in the case of human patients.

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